中国科学院深圳先进技术研究院机构知识库(SIAT OpenIR): Five-year follow-up study of a kidney-tonifying herbal Fufang for prevention of postmenopausal osteoporosis and fragility fractures
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Five-year follow-up study of a kidney-tonifying herbal Fufang for prevention of postmenopausal osteoporosis and fragility fractures
Wei-min Deng; Peng Zhang; Hai Huang; You-gao Shen; Qin-hua Yang; Wei-li Cui; Yang-shu He; Song Wei; Zhu Ye; Fang Liu; Ling Qin
2012
Source PublicationJOURNAL OF BONE AND MINERAL METABOLISM
Subtype期刊论文
AbstractTo observe the kidney-tonifying herbal Fufangs with phytoestrogenic epimedium for prevention of postmenopausal osteoporosis with both bone mineral density (BMD) and fracture as study endpoints, a 5-year multicenter follow-up study in 194 postmenopausal women (47-70 years old) was conducted in which the subjects were given oral administration of herbal Fufang (10 g/day, twice per day, n = 101) or placebo (n = 93). Both groups were supplemented daily with calcium (600 mg) and vitamin D (400 IU). BMD at distal radius, potential adverse events, and fracture incidence were evaluated at baseline and at 6, 12, 24, 36, 48, and 60 months. At the end of 5 years, 155 subjects had completed the study, with better adherence in the treatment group (13% dropouts, n = 88 at year 5) as compared with the control group (28% dropouts, n = 67 at year 5) (P < 0.05). No notable adverse events were observed in either group. In the treatment group BMD increased significantly from baseline (0.211 ± 0.022 g/cm(2)) to the end of the study (0.284 ± 0.015 g/cm(2)), whereas the control group decreased significantly from baseline (0.212 ± 0.023 g/cm(2)) to 5 years later (0.187 ± 0.022 g/cm(2)) (P < 0.05). The fracture incidence was 2.4 fold lower in the treatment group than in the control group, with a relative risk of 0.57 for the treatment group (95% CI, 0.43-0.70, P < 0.05). In conclusion, in addition to the beneficial effects of oral herbal Fufang on prevention of postmenopausal bone loss, this 5-year multi-center clinical study demonstrated for the first time its potential for reduction in fragility fracture incidence.
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Indexed BySCI
Language英语
Department转化医学研究与发展中心
Document Type期刊论文
Identifierhttp://ir.siat.ac.cn/handle/172644/4020
Collection医工所
AffiliationJOURNAL OF BONE AND MINERAL METABOLISM
Recommended Citation
GB/T 7714
Wei-min Deng,Peng Zhang,Hai Huang,et al. Five-year follow-up study of a kidney-tonifying herbal Fufang for prevention of postmenopausal osteoporosis and fragility fractures[J]. JOURNAL OF BONE AND MINERAL METABOLISM,2012.
APA Wei-min Deng.,Peng Zhang.,Hai Huang.,You-gao Shen.,Qin-hua Yang.,...&Ling Qin.(2012).Five-year follow-up study of a kidney-tonifying herbal Fufang for prevention of postmenopausal osteoporosis and fragility fractures.JOURNAL OF BONE AND MINERAL METABOLISM.
MLA Wei-min Deng,et al."Five-year follow-up study of a kidney-tonifying herbal Fufang for prevention of postmenopausal osteoporosis and fragility fractures".JOURNAL OF BONE AND MINERAL METABOLISM (2012).
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