中国科学院深圳先进技术研究院机构知识库(SIAT OpenIR): Natural-Killer-Cell-Inspired Nanorobots with Aggregation-Induced Emission Characteristics for Near-Infrared-II Fluorescence-Guided Glioma Theranostics
SIAT OpenIR  > 医药所
Natural-Killer-Cell-Inspired Nanorobots with Aggregation-Induced Emission Characteristics for Near-Infrared-II Fluorescence-Guided Glioma Theranostics
Guanjun Deng; Xinghua Peng; Zhihong Sun; Wei Zheng; Jia Yu; Lulu Du; Huajie Chen; Ping Gong; Pengfei Zhang; Lintao Cai; Ben Zhong Tang
2020
Source PublicationACS NANO
Subtype期刊论文
AbstractNature has always inspired robotic designs and concepts. It is conceivable that biomimic nanorobots will soon play a prominent role in medicine. The “Terminator” in the science fiction film is the cybernetic organism with living tissue over a metal endoskeleton, which inspired us to develop natural killer cell-mimic nanorobots with aggregation-induced emission (AIE) characteristics (NK@AIEdots) by coating natural kill cell membrane on the AIE-active polymeric endoskeleton, PBPTV, a highly bright NIR-II AIE-active conjugated polymer. Owning to the AIE and soft-matter characteristics of PBPTV, as-prepared NK@AIEdots maintained the superior NIR-II brightness (quantum yield ~7.9 % in water) and good biocompatibility. Besides, they could serve as tight junctions (TJs) modulator to trigger an intracellular signaling cascade, causing TJs disruption and actin cytoskeleton reorganization to form intercellular “green channel” to help themselves crossing Blood-Brain Barriers (BBB) silently. Furthermore, they could initiatively accumulate to glioblastoma cells in the complex brain matrix for high-contrast and through-skull tumor imaging. The tumor growth was also greatly inhibited by these NK@AIEdots under the NIR light illumination. As far as we known, the QY of PBPTV is the highest among the existing NIR-II luminescent conjugated polymers. Besides, the NK-cell biomimetic nanorobots showed great potential for BBB-crossing active delivery.
Indexed BySCI
Language英语
EI Accession Number纳米中心
Document Type期刊论文
Identifierhttp://ir.siat.ac.cn/handle/172644/18197
Collection医药所
Recommended Citation
GB/T 7714
Guanjun Deng,Xinghua Peng,Zhihong Sun,et al. Natural-Killer-Cell-Inspired Nanorobots with Aggregation-Induced Emission Characteristics for Near-Infrared-II Fluorescence-Guided Glioma Theranostics[J]. ACS NANO,2020.
APA Guanjun Deng.,Xinghua Peng.,Zhihong Sun.,Wei Zheng.,Jia Yu.,...&Ben Zhong Tang.(2020).Natural-Killer-Cell-Inspired Nanorobots with Aggregation-Induced Emission Characteristics for Near-Infrared-II Fluorescence-Guided Glioma Theranostics.ACS NANO.
MLA Guanjun Deng,et al."Natural-Killer-Cell-Inspired Nanorobots with Aggregation-Induced Emission Characteristics for Near-Infrared-II Fluorescence-Guided Glioma Theranostics".ACS NANO (2020).
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