中国科学院深圳先进技术研究院机构知识库(SIAT OpenIR): Preparation and characterization of a novel silicon-modified nanobubble.
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Preparation and characterization of a novel silicon-modified nanobubble.
Liu, Jia; Zhang, Bo; Li, Maotong; Zhou, Meijun; Li, Fei; Huang, Xiuxian; Pan, Min; Xue, Li; Yan, Fei
2017
Source PublicationPLOS ONE
Subtype期刊论文
AbstractNanobubbles (NBs) opened a new field of ultrasound imaging. There is still no practical method to control the diameter of bubbles. In this study, we developeda new method to control the size by incorporating of silicon hybrid lipids into the bubble membrane. The range of particle size of resulting NBs is between 523.02 +/- 46.45 to 857.18 +/- 82.90, smaller than the conventional microbubbles. The size of resulting NBs increased with the decrease in amount of silicon hybrid lipids, indicating the diameter of NBs can be regulated through modulating the ratio of silicon hybrid lipids in the bubble shell. Typical harmonic signals could be detected. The in vitro and in vivo ultrasound imaging experiments demonstrated these silicon-modified NBs had significantly improved ultrasound contrast enhancement abilities. Cytotoxicity assays revealed that these NBs had no obvious cytotoxicity to the 293 cell line at the tested bubble concentration. Our results showed that the novel NBs could use as nanoscale ultrasound contrast agents, providing the foundation for NBs in future applications including contrast- enhanced imaging and drug/gene delivery.
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Indexed BySCI
Language英语
Department影像中心
Document Type期刊论文
Identifierhttp://ir.siat.ac.cn/handle/172644/12067
Collection医工所
AffiliationPLOS ONE
Recommended Citation
GB/T 7714
Liu, Jia,Zhang, Bo,Li, Maotong,et al. Preparation and characterization of a novel silicon-modified nanobubble.[J]. PLOS ONE,2017.
APA Liu, Jia.,Zhang, Bo.,Li, Maotong.,Zhou, Meijun.,Li, Fei.,...&Yan, Fei.(2017).Preparation and characterization of a novel silicon-modified nanobubble..PLOS ONE.
MLA Liu, Jia,et al."Preparation and characterization of a novel silicon-modified nanobubble.".PLOS ONE (2017).
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