中国科学院深圳先进技术研究院机构知识库(SIAT OpenIR): Prediction and classification of Alzheimer disease based on quantification of MRI deformation.
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Prediction and classification of Alzheimer disease based on quantification of MRI deformation.
Long, Xiaojing; Chen, Lifang; Jiang, Chunxiang; Zhang, Lijuan
2017
Source PublicationPLOS ONE
Subtype期刊论文
AbstractDetecting early morphological changes in the brain and making early diagnosis are important for Alzheimer's disease (AD). High resolution magnetic resonance imaging can be used to help diagnosis and prediction of the disease. In this paper, we proposed a machine learning method to discriminate patients with AD or mild cognitive impairment (MCI) from healthy elderly and to predict the AD conversion in MCI patients by computing and analyzing the regional morphological differences of brain between groups. Distance between each pair of subjects was quantified from a symmetric diffeomorphic registration, followed by an embedding algorithm and a learning approach for classification. The proposed method obtained accuracy of 96.5% in differentiating mild AD from healthy elderly with the whole-brain gray matter or temporal lobe as region of interest (ROI), 91.74% in differentiating progressive MCI from healthy elderly and 88.99% in classifying progressive MCI versus stable MCI with amygdala or hippocampus as ROI. This deformation-based method has made full use of the pair-wise macroscopic shape difference between groups and consequently increased the power for discrimination.
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Indexed BySCI
Language英语
Department影像中心
Document Type期刊论文
Identifierhttp://ir.siat.ac.cn/handle/172644/12047
Collection医工所
AffiliationPLOS ONE
Recommended Citation
GB/T 7714
Long, Xiaojing,Chen, Lifang,Jiang, Chunxiang,et al. Prediction and classification of Alzheimer disease based on quantification of MRI deformation.[J]. PLOS ONE,2017.
APA Long, Xiaojing,Chen, Lifang,Jiang, Chunxiang,&Zhang, Lijuan.(2017).Prediction and classification of Alzheimer disease based on quantification of MRI deformation..PLOS ONE.
MLA Long, Xiaojing,et al."Prediction and classification of Alzheimer disease based on quantification of MRI deformation.".PLOS ONE (2017).
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