中国科学院深圳先进技术研究院机构知识库(SIAT OpenIR): Activation of the dopaminergic pathway from VTA to the medial olfactory tubercle generates odor-preference and reward
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Activation of the dopaminergic pathway from VTA to the medial olfactory tubercle generates odor-preference and reward
Zhijian Zhang; Qing Liu; Pengjie Wen; Jiaozhen Zhang; Xiaoping Rao; Ziming Zhou; Hongruo Zhang; Xiaobin He; Juan Li; Zheng Zhou; Xiaoran Xu; Xueyi Zhang; Rui Luo; Guanghui Lv; Haohong Li; Pei Cao; Liping Wang; Fuqiang Xu
2017
Source PublicationeLife
Subtype期刊论文
AbstractOdor-preferences are usually influenced by life experiences. However, the neural circuit mechanisms remain unclear. The medial olfactory tubercle (mOT) is involved in both reward and olfaction, while the ventral tegmental area (VTA) dopaminergic (DAergic) neurons are considered to be engaged in reward and motivation. Here, we found that the VTA (DAergic)-mOT pathway could be activated by different types of naturalistic rewards as well as odors in DAT-cre mice. Optogenetic activation of the VTA-mOT DAergic fibers was able to elicit preferences for space, location and neutral odor, while pharmacological blockade of the dopamine receptors in the mOT fully prevented the odor-preference formation. Furthermore, inactivation of the mOT-projecting VTA DAergic neurons eliminated the previously formed odor-preference and strongly affected the Go-no go learning efficiency. In summary, our results revealed that the VTA (DAergic)-mOT pathway mediates a variety of naturalistic reward processes and different types of preferences including odor-preference in mice.
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Indexed BySCI
Language英语
WOS IDWOS:000423033300001
Department脑图谱中心
Citation statistics
Document Type期刊论文
Identifierhttp://ir.siat.ac.cn/handle/172644/11919
Collection脑所
AffiliationeLife
Recommended Citation
GB/T 7714
Zhijian Zhang,Qing Liu,Pengjie Wen,et al. Activation of the dopaminergic pathway from VTA to the medial olfactory tubercle generates odor-preference and reward[J]. eLife,2017.
APA Zhijian Zhang.,Qing Liu.,Pengjie Wen.,Jiaozhen Zhang.,Xiaoping Rao.,...&Fuqiang Xu.(2017).Activation of the dopaminergic pathway from VTA to the medial olfactory tubercle generates odor-preference and reward.eLife.
MLA Zhijian Zhang,et al."Activation of the dopaminergic pathway from VTA to the medial olfactory tubercle generates odor-preference and reward".eLife (2017).
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