中国科学院深圳先进技术研究院机构知识库(SIAT OpenIR): Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity
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Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity
Liu, Ke; Lei, Run; Li, Qiong; Wang, Xin-Xin; Wu, Qian; An, Peng; Zhang, Jianchao; Zhu, Minyan; Xu, Zhiheng; Hong, Yang; Wang, Fudi; Shen, Ying; Li, Hongchang; Li, Huashun
2016
Source PublicationSCIENTIFIC REPORTS
Subtype期刊论文
AbstractTransferrin receptor (TFR) is an important iron transporter regulating iron homeostasis and has long been used as a marker for clathrin mediated endocytosis. However, little is known about its additional function other than iron transport in the development of central nervous system (CNS). Here we demonstrate that TFR functions as a regulator to control AMPA receptor trafficking efficiency and synaptic plasticity. The conditional knockout (KO) of TFR in neural progenitor cells causes mice to develop progressive epileptic seizure, and dramatically reduces basal synaptic transmission and long-term potentiation (LTP). We further demonstrate that TFR KO remarkably reduces the binding efficiency of GluR2 to AP2 and subsequently decreases AMPA receptor endocytosis and recycling. Thus, our study reveals that TFR functions as a novel regulator to control AMPA trafficking efficiency and synaptic plasticity.
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Indexed BySCI
Language英语
Department纳米中心
Document Type期刊论文
Identifierhttp://ir.siat.ac.cn/handle/172644/10684
Collection医药所
AffiliationSCIENTIFIC REPORTS
Recommended Citation
GB/T 7714
Liu, Ke,Lei, Run,Li, Qiong,et al. Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity[J]. SCIENTIFIC REPORTS,2016.
APA Liu, Ke.,Lei, Run.,Li, Qiong.,Wang, Xin-Xin.,Wu, Qian.,...&Li, Huashun.(2016).Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity.SCIENTIFIC REPORTS.
MLA Liu, Ke,et al."Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity".SCIENTIFIC REPORTS (2016).
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